Assay Detail
Binding
CHEMBL4345183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-terminal Avi-tagged AAK1 kinase domain (31 to 396 residues) (unknown origin) expressed in Escherichia coli measured after 1.5 hrs by TR-FRET assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.76 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571548 | — | — | 1 | 8.21 |
| CHEMBL4534959 | — | — | 1 | 8.20 |
| CHEMBL4531680 | — | — | 1 | 8.09 |
| CHEMBL4516665 | — | — | 1 | 8.08 |
| CHEMBL4535040 | — | — | 1 | 8.07 |
| CHEMBL4452939 | — | — | 1 | 8.04 |
| CHEMBL4452360 | — | — | 1 | 8.00 |
| CHEMBL4552310 | — | — | 1 | 7.92 |
| CHEMBL4470026 | — | — | 1 | 7.70 |
| CHEMBL4473140 | — | — | 1 | 7.66 |
| CHEMBL4542463 | — | — | 1 | 7.66 |
| CHEMBL4593649 | — | — | 1 | 7.62 |
| CHEMBL4522276 | — | — | 1 | 7.52 |
| CHEMBL4447403 | — | — | 1 | 7.50 |
| CHEMBL4472438 | — | — | 1 | 7.48 |
| CHEMBL4582326 | — | — | 1 | 7.41 |
| CHEMBL4561238 | — | — | 1 | 7.36 |
| CHEMBL4534571 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571548 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL4534959 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4531680 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4516665 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL4535040 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4452939 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL4452360 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4552310 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4470026 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4473140 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4542463 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4593649 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL4522276 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4447403 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL4472438 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4582326 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL4561238 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL4534571 | — | Ki | = | 59.0 | nM | 7.23 |