Compound Detail
CHEMBL4452360
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Basic Information
| ChEMBL ID | CHEMBL4452360 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GXQWWDBZTZLIAJ-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
399.5
MW (Da)
2.80
ALogP
4
HBA
3
HBD
107.2
PSA (Ų)
0.59
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| AP2-associated protein kinase 1 CHEMBL3830 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| BMP-2-inducible protein kinase CHEMBL4522 | Ki | 7.72 | 7.72 | 19.0 | 1 |
| Serine/threonine-protein kinase 16 CHEMBL3938 | Ki | 6.46 | 6.46 | 350.0 | 1 |
| Cyclin-G-associated kinase CHEMBL4355 | Ki | 5.58 | 5.58 | 2600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| AP2-associated protein kinase 1 | Ki | = | 10.0 | nM | 8.0 | Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-termina... | 32184967 |
| BMP-2-inducible protein kinase | Ki | = | 19.0 | nM | 7.72 | Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-termina... | 32184967 |
| Serine/threonine-protein kinase 16 | Ki | = | 350.0 | nM | 6.46 | Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-termina... | 32184967 |
| Cyclin-G-associated kinase | Ki | = | 2600.0 | nM | 5.58 | Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-termina... | 32184967 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32184967 | 10.1021/acsmedchemlett.9b00399 | Unchecked | 4 |
| 32184967 | 10.1021/acsmedchemlett.9b00399 | AP2-associated protein kinase 1 | 2 |
| 32184967 | 10.1021/acsmedchemlett.9b00399 | BMP-2-inducible protein kinase | 1 |
| 32184967 | 10.1021/acsmedchemlett.9b00399 | Cyclin-G-associated kinase | 1 |
| 32184967 | 10.1021/acsmedchemlett.9b00399 | Serine/threonine-protein kinase 16 | 1 |
Data from ChEMBL 36 via Core Engine