Assay Detail
Functional
CHEMBL4345977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 Env-pseudotyped virus in human U87.CD4.CCR5 target cells assessed as reduction in viral infection at late stage
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229713 | — | — | 1 | 6.64 |
| CHEMBL4471665 | — | — | 1 | 6.62 |
| CHEMBL4436876 | — | — | 1 | 5.61 |
| CHEMBL4571968 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229713 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4471665 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4436876 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL4571968 | — | IC50 | = | 4200.0 | nM | 5.38 |