Assay Detail
Functional
CHEMBL4346008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cell death incubated for 5 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.67 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471665 | — | — | 1 | 6.68 |
| CHEMBL4459072 | — | — | 1 | 6.15 |
| CHEMBL1229713 | — | — | 1 | 6.06 |
| CHEMBL4566312 | — | — | 1 | 5.31 |
| CHEMBL4436876 | — | — | 1 | 5.22 |
| CHEMBL4571968 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471665 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4459072 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1229713 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4566312 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4436876 | — | EC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL4571968 | — | EC50 | = | 24480.0 | nM | 4.61 |