Assay Detail
Binding
CHEMBL4348569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of human GABA-A alpha1beta2gamma2S receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride channel current by two-electrode voltage clamp method relative to control
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-2/gamma-2 (CHEMBL2095172) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.73 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52229 | OSTHOLE | — | 1 | 4.85 |
| CHEMBL510120 | OXYPEUCEDANIN | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52229 | OSTHOLE | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL510120 | OXYPEUCEDANIN | EC50 | = | 25000.0 | nM | 4.60 |