Assay Detail
Functional
CHEMBL4350264
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Antitrypanosomal activity against suramin sensitive Trypanosoma brucei Squib427 trypomastigotes assessed as reduction in parasitic cell viability measured after 72 hrs by resazurin dye based fluorimetric analysis
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.84 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519708 | — | — | 2 | 6.22 |
| CHEMBL4464777 | — | — | 2 | 6.22 |
| CHEMBL4465919 | — | — | 1 | 6.00 |
| CHEMBL4473824 | — | — | 1 | 5.40 |
| CHEMBL4210475 | — | — | 1 | 5.30 |
| CHEMBL4204999 | — | — | 1 | 5.20 |
| CHEMBL4520514 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519708 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4464777 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4519708 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4464777 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4465919 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4473824 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4210475 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4204999 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4520514 | — | IC50 | > | 63095.73 | nM | - |