Assay Detail
Functional
CHEMBL4350852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei Squib 427 trypomastigotes assessed as reduction in parasite growth incubated for 72 hrs by resazurin dye-based fluorimetric analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.58 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.40 |
| CHEMBL4436770 | — | — | 1 | 6.20 |
| CHEMBL4465919 | — | — | 1 | 6.00 |
| CHEMBL4454951 | — | — | 1 | 6.00 |
| CHEMBL4521383 | — | — | 1 | 6.00 |
| CHEMBL4445930 | — | — | 1 | 5.90 |
| CHEMBL4453045 | — | — | 1 | 5.80 |
| CHEMBL4439778 | — | — | 1 | 5.80 |
| CHEMBL4443772 | — | — | 1 | 5.70 |
| CHEMBL4520014 | — | — | 1 | 5.70 |
| CHEMBL4445489 | — | — | 1 | 5.70 |
| CHEMBL4566533 | — | — | 1 | 5.70 |
| CHEMBL4444414 | — | — | 1 | 5.60 |
| CHEMBL4439798 | — | — | 1 | 5.60 |
| CHEMBL4439032 | — | — | 1 | 5.50 |
| CHEMBL4516631 | — | — | 1 | 5.30 |
| CHEMBL4463356 | — | — | 1 | 5.20 |
| CHEMBL4473629 | — | — | 1 | 5.20 |
| CHEMBL4435831 | — | — | 1 | 5.10 |
| CHEMBL4583339 | — | — | 1 | 5.10 |
| CHEMBL4453613 | — | — | 1 | 5.10 |
| CHEMBL4565967 | — | — | 1 | 5.10 |
| CHEMBL4522881 | — | — | 1 | 5.10 |
| CHEMBL4472788 | — | — | 1 | 5.00 |
| CHEMBL4562476 | — | — | 1 | 4.60 |
| CHEMBL4471782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4436770 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4465919 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4454951 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4521383 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4445930 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4453045 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4439778 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4443772 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4520014 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4445489 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4566533 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4444414 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4439798 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4439032 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4516631 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4463356 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4473629 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4435831 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4583339 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4453613 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4565967 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4522881 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4472788 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4562476 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4471782 | — | IC50 | > | 63095.73 | nM | - |