Assay Detail
Binding
CHEMBL4351325
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Displacement of (RS)-[3H]AMPA from recombinant rat GluA1 expressed in baculovirus infected Sf9 insect cell membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.70 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94859 | — | — | 1 | 8.28 |
| CHEMBL276815 | (S)-AMPA | — | 1 | 7.66 |
| CHEMBL4529665 | — | — | 1 | 5.04 |
| CHEMBL3742451 | — | — | 1 | 4.80 |
| CHEMBL4556711 | — | — | 1 | 4.27 |
| CHEMBL3742450 | — | — | 1 | 4.14 |
| CHEMBL4448290 | — | — | 1 | - |
| CHEMBL4451018 | — | — | 1 | - |
| CHEMBL388746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94859 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL276815 | (S)-AMPA | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4529665 | — | Ki | = | 9020.0 | nM | 5.04 |
| CHEMBL3742451 | — | Ki | = | 15700.0 | nM | 4.80 |
| CHEMBL4556711 | — | Ki | = | 54100.0 | nM | 4.27 |
| CHEMBL3742450 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL4448290 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4451018 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL388746 | — | Ki | = | 7700.0 | nM | - |