Assay Detail
Functional
CHEMBL4352680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
47
Total Activities
47
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pEC50 | 43 | - | - |
| EC50 | 4 | 7.20 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454594 | — | — | 1 | 7.29 |
| CHEMBL4536334 | — | — | 1 | 7.28 |
| CHEMBL379761 | — | — | 1 | 7.02 |
| CHEMBL4581435 | — | — | 1 | - |
| CHEMBL4436692 | — | — | 1 | - |
| CHEMBL4581717 | — | — | 1 | - |
| CHEMBL4536766 | — | — | 1 | - |
| CHEMBL4459219 | — | — | 1 | - |
| CHEMBL4549305 | — | — | 1 | - |
| CHEMBL4532583 | — | — | 1 | - |
| CHEMBL4556579 | — | — | 1 | - |
| CHEMBL4551649 | — | — | 1 | - |
| CHEMBL4448213 | — | — | 1 | - |
| CHEMBL4581644 | — | — | 1 | - |
| CHEMBL4446663 | — | — | 1 | - |
| CHEMBL4440250 | — | — | 1 | - |
| CHEMBL4551842 | — | — | 1 | - |
| CHEMBL4517103 | — | — | 1 | - |
| CHEMBL4447830 | — | — | 1 | - |
| CHEMBL4476616 | — | — | 1 | - |
| CHEMBL4549250 | — | — | 1 | - |
| CHEMBL4447632 | — | — | 1 | - |
| CHEMBL4560787 | — | — | 1 | - |
| CHEMBL4568124 | — | — | 1 | - |
| CHEMBL4436651 | — | — | 1 | - |
| CHEMBL4440569 | — | — | 1 | - |
| CHEMBL4453208 | — | — | 1 | - |
| CHEMBL4452950 | — | — | 1 | - |
| CHEMBL4569975 | — | — | 1 | - |
| CHEMBL4543016 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454594 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL4536334 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL379761 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL4459219 | — | pEC50 | - | — | - | |
| CHEMBL4473444 | — | pEC50 | - | — | - | |
| CHEMBL4536766 | — | pEC50 | - | — | - | |
| CHEMBL4581717 | — | pEC50 | - | — | - | |
| CHEMBL4436692 | — | pEC50 | - | — | - | |
| CHEMBL4581435 | — | pEC50 | - | — | - | |
| CHEMBL4514037 | — | pEC50 | - | — | - | |
| CHEMBL4583846 | — | pEC50 | - | — | - | |
| CHEMBL4539397 | — | pEC50 | - | — | - | |
| CHEMBL4457243 | — | pEC50 | - | — | - | |
| CHEMBL4472897 | — | pEC50 | - | — | - | |
| CHEMBL4571633 | — | pEC50 | - | — | - | |
| CHEMBL4547975 | — | pEC50 | - | — | - | |
| CHEMBL556625 | — | pEC50 | - | — | - | |
| CHEMBL551589 | — | pEC50 | - | — | - | |
| CHEMBL4442702 | — | pEC50 | - | — | - | |
| CHEMBL4465768 | — | pEC50 | - | — | - | |
| CHEMBL4448576 | — | pEC50 | - | — | - | |
| CHEMBL4447184 | — | pEC50 | - | — | - | |
| CHEMBL4440608 | — | pEC50 | - | — | - | |
| CHEMBL4588649 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4456812 | — | pEC50 | - | — | - | |
| CHEMBL4476616 | — | pEC50 | - | — | - | |
| CHEMBL4543016 | — | pEC50 | - | — | - | |
| CHEMBL4569975 | — | pEC50 | - | — | - | |
| CHEMBL4452950 | — | pEC50 | - | — | - | |
| CHEMBL4453208 | — | pEC50 | - | — | - | |
| CHEMBL4440569 | — | pEC50 | - | — | - | |
| CHEMBL4436651 | — | pEC50 | - | — | - | |
| CHEMBL4568124 | — | pEC50 | - | — | - | |
| CHEMBL4560787 | — | pEC50 | - | — | - | |
| CHEMBL4447632 | — | pEC50 | - | — | - | |
| CHEMBL4549250 | — | pEC50 | - | — | - | |
| CHEMBL4549305 | — | pEC50 | - | — | - | |
| CHEMBL4447830 | — | pEC50 | - | — | - | |
| CHEMBL4517103 | — | pEC50 | - | — | - | |
| CHEMBL4551842 | — | pEC50 | - | — | - | |
| CHEMBL4440250 | — | pEC50 | - | — | - | |
| CHEMBL4446663 | — | pEC50 | - | — | - | |
| CHEMBL4581644 | — | pEC50 | - | — | - | |
| CHEMBL4448213 | — | pEC50 | - | — | - | |
| CHEMBL4551649 | — | pEC50 | - | — | - | |
| CHEMBL4556579 | — | pEC50 | - | — | - | |
| CHEMBL4532583 | — | pEC50 | - | — | - |