Assay Detail
Functional
CHEMBL4352682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
48
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 48 | 6.00 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4532583 | — | — | 1 | 8.19 |
| CHEMBL379761 | — | — | 1 | 7.49 |
| CHEMBL4536334 | — | — | 1 | 7.26 |
| CHEMBL4447830 | — | — | 1 | 6.81 |
| CHEMBL4447632 | — | — | 1 | 6.65 |
| CHEMBL4454594 | — | — | 2 | 6.22 |
| CHEMBL4476616 | — | — | 1 | 5.55 |
| CHEMBL4551649 | — | — | 1 | 5.28 |
| CHEMBL4549250 | — | — | 1 | 5.20 |
| CHEMBL4551842 | — | — | 1 | 5.01 |
| CHEMBL4448213 | — | — | 1 | 4.94 |
| CHEMBL4442702 | — | — | 1 | 4.76 |
| CHEMBL4588649 | — | — | 1 | 4.60 |
| CHEMBL4436692 | — | — | 1 | - |
| CHEMBL4581717 | — | — | 1 | - |
| CHEMBL4536766 | — | — | 1 | - |
| CHEMBL4459219 | — | — | 1 | - |
| CHEMBL4571633 | — | — | 1 | - |
| CHEMBL4556579 | — | — | 1 | - |
| CHEMBL4581644 | — | — | 1 | - |
| CHEMBL4446663 | — | — | 1 | - |
| CHEMBL4440250 | — | — | 1 | - |
| CHEMBL4517103 | — | — | 1 | - |
| CHEMBL4560787 | — | — | 1 | - |
| CHEMBL4569975 | — | — | 1 | - |
| CHEMBL4453208 | — | — | 1 | - |
| CHEMBL4440569 | — | — | 1 | - |
| CHEMBL4436651 | — | — | 1 | - |
| CHEMBL4452950 | — | — | 1 | - |
| CHEMBL4568124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4532583 | — | EC50 | = | 6.457 | nM | 8.19 |
| CHEMBL379761 | — | EC50 | = | 32.36 | nM | 7.49 |
| CHEMBL4536334 | — | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL4447830 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL4447632 | — | EC50 | = | 223.87 | nM | 6.65 |
| CHEMBL4454594 | — | EC50 | = | 603.0 | nM | 6.22 |
| CHEMBL4454594 | — | EC50 | = | 891.25 | nM | 6.05 |
| CHEMBL4476616 | — | EC50 | = | 2818.38 | nM | 5.55 |
| CHEMBL4551649 | — | EC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL4549250 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4551842 | — | EC50 | = | 9772.37 | nM | 5.01 |
| CHEMBL4448213 | — | EC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL4442702 | — | EC50 | = | 17378.01 | nM | 4.76 |
| CHEMBL4588649 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4514037 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4547975 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4583846 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4539397 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4457243 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4472897 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4571633 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4452950 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL556625 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL551589 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4465768 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4448576 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4447184 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4440608 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4456812 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4473444 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4569975 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4436651 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4440250 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4543016 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4517103 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4446663 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4581644 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4556579 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4560787 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4568124 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4581435 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4440569 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4453208 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4549305 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4459219 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4536766 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4581717 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4436692 | — | EC50 | > | 100000.0 | nM | - |