Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4352683

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL ↗
48
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

fMet-Leu-Phe receptor (CHEMBL3359) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists.
Deora GS, Qin CX, Vecchio EA, Debono AJ, Priebbenow DL, Brady RM, Beveridge J, Teguh SC, Deo M, May LT, Krippner G, Ritchie RH, Baell JB.
J Med Chem (2019) 62 : 5242 -5248
PubMed 31038950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 48 5.96 7.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL379761 — — 1 7.29
CHEMBL4454594 — — 2 7.08
CHEMBL4536334 — — 1 7.03
CHEMBL4551649 — — 1 6.90
CHEMBL4447830 — — 1 6.84
CHEMBL4448213 — — 1 6.83
CHEMBL4447632 — — 1 6.77
CHEMBL4532583 — — 1 6.61
CHEMBL4581644 — — 1 6.48
CHEMBL4465768 — — 1 6.07
CHEMBL4536766 — — 1 5.91
CHEMBL4442702 — — 1 5.86
CHEMBL4448576 — — 1 5.75
CHEMBL4436651 — — 1 5.74
CHEMBL4517103 — — 1 5.73
CHEMBL4543016 — — 1 5.68
CHEMBL556625 — — 1 5.65
CHEMBL4476616 — — 1 5.58
CHEMBL4440569 — — 1 5.58
CHEMBL4440250 — — 1 5.55
CHEMBL4588649 — — 1 5.47
CHEMBL4539397 — — 1 5.30
CHEMBL4452950 — — 1 5.25
CHEMBL551589 — — 1 5.22
CHEMBL4551842 — — 1 5.20
CHEMBL4473444 — — 1 5.12
CHEMBL4583846 — — 1 5.10
CHEMBL4569975 — — 1 5.07
CHEMBL4549250 — — 1 5.00
CHEMBL4514037 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL379761 — EC50 = 51.29 nM 7.29
CHEMBL4454594 — EC50 = 83.0 nM 7.08
CHEMBL4454594 — EC50 = 83.18 nM 7.08
CHEMBL4536334 — EC50 = 93.33 nM 7.03
CHEMBL4551649 — EC50 = 125.89 nM 6.90
CHEMBL4447830 — EC50 = 144.54 nM 6.84
CHEMBL4448213 — EC50 = 147.91 nM 6.83
CHEMBL4447632 — EC50 = 169.82 nM 6.77
CHEMBL4532583 — EC50 = 245.47 nM 6.61
CHEMBL4581644 — EC50 = 331.13 nM 6.48
CHEMBL4465768 — EC50 = 851.14 nM 6.07
CHEMBL4536766 — EC50 = 1230.27 nM 5.91
CHEMBL4442702 — EC50 = 1380.38 nM 5.86
CHEMBL4448576 — EC50 = 1778.28 nM 5.75
CHEMBL4436651 — EC50 = 1819.7 nM 5.74
CHEMBL4517103 — EC50 = 1862.09 nM 5.73
CHEMBL4543016 — EC50 = 2089.3 nM 5.68
CHEMBL556625 — EC50 = 2238.72 nM 5.65
CHEMBL4476616 — EC50 = 2630.27 nM 5.58
CHEMBL4440569 — EC50 = 2630.27 nM 5.58
CHEMBL4440250 — EC50 = 2818.38 nM 5.55
CHEMBL4588649 — EC50 = 3388.44 nM 5.47
CHEMBL4539397 — EC50 = 5011.87 nM 5.30
CHEMBL4452950 — EC50 = 5623.41 nM 5.25
CHEMBL551589 — EC50 = 6025.6 nM 5.22
CHEMBL4551842 — EC50 = 6309.57 nM 5.20
CHEMBL4473444 — EC50 = 7585.78 nM 5.12
CHEMBL4583846 — EC50 = 7943.28 nM 5.10
CHEMBL4569975 — EC50 = 8511.38 nM 5.07
CHEMBL4549250 — EC50 = 10000.0 nM 5.00
CHEMBL4571633 — EC50 > 100000.0 nM -
CHEMBL4447184 — EC50 > 100000.0 nM -
CHEMBL4440608 — EC50 > 100000.0 nM -
CHEMBL4456812 — EC50 > 100000.0 nM -
CHEMBL4453208 — EC50 > 100000.0 nM -
CHEMBL4568124 — EC50 > 100000.0 nM -
CHEMBL4560787 — EC50 > 100000.0 nM -
CHEMBL4472897 — EC50 > 100000.0 nM -
CHEMBL4457243 — EC50 > 100000.0 nM -
CHEMBL4446663 — EC50 > 100000.0 nM -
CHEMBL4556579 — EC50 > 100000.0 nM -
CHEMBL4547975 — EC50 > 100000.0 nM -
CHEMBL4459219 — EC50 > 100000.0 nM -
CHEMBL4581435 — EC50 > 100000.0 nM -
CHEMBL4514037 — EC50 > 100000.0 nM -
CHEMBL4549305 — EC50 > 100000.0 nM -
CHEMBL4436692 — EC50 > 100000.0 nM -
CHEMBL4581717 — EC50 > 100000.0 nM -