Assay Detail

CHEMBL4355180

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Functional

Antiproliferative activity against human DU145 cells assessed as reduction in viability after 48 hrs by MTTS assay

ChEMBL ↗

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Target

DU-145 (CHEMBL613508) ↗

Open DB target context

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Primary target DU-145

CHEMBL613508

Anchored from Assay target.

Protein identity DU-145

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	DU-145
Confidence	1 — Organism
Curated By	Autocuration

Target

DU-145 (CHEMBL613508) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Potential Anticancer Agents Characterized from Selected Tropical Plants.

Ren Y, de Blanco EJC, Fuchs JR, Soejarto DD, Burdette JE, Swanson SM, Kinghorn AD.
J Nat Prod (2019) 82 : 657 -679
PubMed 30830783 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.92	7.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL495949	CALOTROPIN	—	1	7.52
CHEMBL495033	CALOTROPAGENIN	—	1	6.32

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL495949	CALOTROPIN	IC50	=	30.0	nM	7.52
CHEMBL495033	CALOTROPAGENIN	IC50	=	480.0	nM	6.32