Assay Detail
Functional
CHEMBL4359392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 expressing RT Y181C mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.85 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 8.32 |
| CHEMBL4094163 | — | — | 1 | 8.30 |
| CHEMBL4526732 | — | — | 1 | 8.18 |
| CHEMBL4464036 | — | — | 1 | 7.89 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.80 |
| CHEMBL4580098 | — | — | 1 | 7.75 |
| CHEMBL4466741 | — | — | 1 | 7.51 |
| CHEMBL4520544 | — | — | 1 | 7.48 |
| CHEMBL4437897 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 4.73 | nM | 8.32 |
| CHEMBL4094163 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4526732 | — | EC50 | = | 6.57 | nM | 8.18 |
| CHEMBL4464036 | — | EC50 | = | 12.8 | nM | 7.89 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 15.7 | nM | 7.80 |
| CHEMBL4580098 | — | EC50 | = | 17.7 | nM | 7.75 |
| CHEMBL4466741 | — | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL4520544 | — | EC50 | = | 32.8 | nM | 7.48 |
| CHEMBL4437897 | — | EC50 | = | 36.3 | nM | 7.44 |