Assay Detail
Functional
CHEMBL4359395
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 expressing RT F227L + V106A mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.68 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094163 | — | — | 1 | 8.57 |
| CHEMBL4526732 | — | — | 1 | 8.32 |
| CHEMBL4580098 | — | — | 1 | 7.91 |
| CHEMBL4464036 | — | — | 1 | 7.82 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.53 |
| CHEMBL4520544 | — | — | 1 | 7.49 |
| CHEMBL4466741 | — | — | 1 | 7.49 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 7.09 |
| CHEMBL4437897 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094163 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4526732 | — | EC50 | = | 4.81 | nM | 8.32 |
| CHEMBL4580098 | — | EC50 | = | 12.2 | nM | 7.91 |
| CHEMBL4464036 | — | EC50 | = | 15.1 | nM | 7.82 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 29.4 | nM | 7.53 |
| CHEMBL4520544 | — | EC50 | = | 32.6 | nM | 7.49 |
| CHEMBL4466741 | — | EC50 | = | 32.1 | nM | 7.49 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 81.6 | nM | 7.09 |
| CHEMBL4437897 | — | EC50 | = | 127.0 | nM | 6.90 |