Assay Detail
Functional
CHEMBL4359684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.40 |
| CHEMBL4460245 | — | — | 1 | 7.66 |
| CHEMBL4436271 | — | — | 1 | 7.08 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.92 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 6.30 |
| CHEMBL4446403 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4460245 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4436271 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL4446403 | — | IC50 | = | 614.0 | nM | 6.21 |