Assay Detail
Binding
CHEMBL4361358
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Inhibition of rabbit muscle Glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of AMP
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.33 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594021 | — | — | 1 | 6.20 |
| CHEMBL4514774 | — | — | 1 | 5.68 |
| CHEMBL510975 | — | — | 1 | 5.51 |
| CHEMBL489798 | — | — | 1 | 5.29 |
| CHEMBL4514550 | — | — | 1 | 5.05 |
| CHEMBL4441560 | — | — | 1 | 4.89 |
| CHEMBL594972 | — | — | 1 | 4.71 |
| CHEMBL4446608 | — | — | 1 | - |
| CHEMBL595439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594021 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL4514774 | — | Ki | = | 2110.0 | nM | 5.68 |
| CHEMBL510975 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL489798 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL4514550 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4441560 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL594972 | — | Ki | = | 19600.0 | nM | 4.71 |
| CHEMBL4446608 | — | Ki | = | 136000.0 | nM | - |
| CHEMBL595439 | — | Ki | = | 105000.0 | nM | - |