Assay Detail
Binding
CHEMBL4361954
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.08 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4466918 | — | — | 1 | 9.22 |
| CHEMBL4441152 | — | — | 1 | 8.92 |
| CHEMBL4585585 | — | — | 1 | 8.70 |
| CHEMBL4443578 | — | — | 1 | 8.64 |
| CHEMBL4576023 | — | — | 1 | 8.51 |
| CHEMBL4513439 | — | — | 1 | 8.41 |
| CHEMBL4459275 | — | — | 1 | 8.41 |
| CHEMBL4443361 | — | — | 1 | 8.37 |
| CHEMBL4439604 | — | — | 1 | 8.34 |
| CHEMBL4474456 | — | — | 1 | 8.30 |
| CHEMBL4455556 | — | — | 1 | 8.20 |
| CHEMBL4471724 | — | — | 1 | 8.16 |
| CHEMBL4584616 | — | — | 1 | 8.06 |
| CHEMBL4447938 | — | — | 1 | 8.00 |
| CHEMBL4450450 | — | — | 1 | 8.00 |
| CHEMBL4470668 | — | — | 1 | 7.94 |
| CHEMBL4441313 | — | — | 1 | 7.76 |
| CHEMBL4519484 | — | — | 1 | 7.68 |
| CHEMBL4462505 | — | — | 1 | 7.34 |
| CHEMBL4518587 | — | — | 1 | 7.34 |
| CHEMBL4453509 | — | — | 1 | 6.77 |
| CHEMBL4441357 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466918 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4441152 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4585585 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4443578 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4576023 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4513439 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4459275 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4443361 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4439604 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4474456 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4455556 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4471724 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4584616 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4447938 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL4450450 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4470668 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4441313 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL4519484 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4462505 | — | IC50 | = | 45.4 | nM | 7.34 |
| CHEMBL4518587 | — | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL4453509 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4441357 | — | IC50 | = | 198.0 | nM | 6.70 |