Assay Detail
Binding
CHEMBL4361983
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Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured for 125 secs by Ellman's method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.16 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4588525 | — | — | 1 | 8.72 |
| CHEMBL4545701 | — | — | 1 | 8.34 |
| CHEMBL4555120 | — | — | 1 | 8.15 |
| CHEMBL4572757 | — | — | 1 | 8.10 |
| CHEMBL4536715 | — | — | 1 | 7.96 |
| CHEMBL4483710 | — | — | 1 | 7.92 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.77 |
| CHEMBL4469822 | — | — | 1 | 7.66 |
| CHEMBL4550977 | — | — | 1 | 7.66 |
| CHEMBL4535585 | — | — | 1 | 7.60 |
| CHEMBL4475228 | — | — | 1 | 7.54 |
| CHEMBL1783191 | — | — | 1 | 7.52 |
| CHEMBL4076034 | — | — | 1 | 7.51 |
| CHEMBL4589250 | — | — | 1 | 7.37 |
| CHEMBL4521755 | — | — | 1 | 7.29 |
| CHEMBL3182739 | — | — | 1 | 6.89 |
| CHEMBL4575976 | — | — | 1 | 6.74 |
| CHEMBL4564873 | — | — | 1 | 6.57 |
| CHEMBL4560263 | — | — | 1 | 6.20 |
| CHEMBL4534033 | — | — | 1 | 6.15 |
| CHEMBL4450123 | — | — | 1 | 5.92 |
| CHEMBL4549672 | — | — | 1 | 5.72 |
| CHEMBL4517722 | — | — | 1 | 5.53 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4588525 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4545701 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4555120 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4572757 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL4536715 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4483710 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL95 | TACRINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4469822 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4550977 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4535585 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4475228 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1783191 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4076034 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4589250 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL4521755 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL3182739 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL4575976 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL4564873 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL4560263 | — | Ki | = | 637.0 | nM | 6.20 |
| CHEMBL4534033 | — | Ki | = | 704.0 | nM | 6.15 |
| CHEMBL4450123 | — | Ki | = | 1202.0 | nM | 5.92 |
| CHEMBL4549672 | — | Ki | = | 1898.0 | nM | 5.72 |
| CHEMBL4517722 | — | Ki | = | 2925.0 | nM | 5.53 |
| CHEMBL659 | GALANTAMINE | Ki | = | 7700.0 | nM | 5.11 |