Assay Detail
Binding
CHEMBL4362206
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Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.42 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL4567642 | — | — | 1 | 7.13 |
| CHEMBL4466188 | — | — | 1 | 7.09 |
| CHEMBL4475227 | — | — | 1 | 7.07 |
| CHEMBL1096882 | FLUDARABINE PHOSPHATE | 4.0 | 1 | 6.88 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 6.88 |
| CHEMBL1201754 | RUFINAMIDE | 4.0 | 1 | 6.46 |
| CHEMBL507042 | — | — | 1 | 6.27 |
| CHEMBL4444937 | — | — | 1 | 6.00 |
| CHEMBL4518150 | — | — | 1 | 5.94 |
| CHEMBL3195633 | — | — | 1 | 5.06 |
| CHEMBL4472009 | — | — | 1 | 5.01 |
| CHEMBL4440525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL4567642 | — | Ki | = | 73.4 | nM | 7.13 |
| CHEMBL4466188 | — | Ki | = | 80.9 | nM | 7.09 |
| CHEMBL4475227 | — | Ki | = | 84.3 | nM | 7.07 |
| CHEMBL1096882 | FLUDARABINE PHOSPHATE | Ki | = | 130.9 | nM | 6.88 |
| CHEMBL1289601 | LENVATINIB | Ki | = | 132.7 | nM | 6.88 |
| CHEMBL1201754 | RUFINAMIDE | Ki | = | 343.8 | nM | 6.46 |
| CHEMBL507042 | — | Ki | = | 538.9 | nM | 6.27 |
| CHEMBL4444937 | — | Ki | = | 996.9 | nM | 6.00 |
| CHEMBL4518150 | — | Ki | = | 1151.6 | nM | 5.94 |
| CHEMBL3195633 | — | Ki | = | 8707.9 | nM | 5.06 |
| CHEMBL4472009 | — | Ki | = | 9754.7 | nM | 5.01 |
| CHEMBL4440525 | — | Ki | > | 10000.0 | nM | - |