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Assay Detail

CHEMBL4366188

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against MDCK cells incubated for 72 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Canis lupus familiaris
Cell Type MDCK
Confidence 1 — Organism
Curated By Autocuration

Target

MDCK (CHEMBL614068)
Type CELL-LINE
Organism Canis lupus familiaris

Publication

Synthesis and biological activity of glycyrrhetinic acid derivatives as antitumor agents.
Zhou F, Wu GR, Cai DS, Xu B, Yan MM, Ma T, Guo WB, Zhang WX, Huang XM, Jia XH, Yang YQ, Gao F, Wang PL, Lei HM.
Eur J Med Chem (2019) 178 : 623 -635
PubMed 31226654 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 5.20 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4451839 1 5.60
CHEMBL4559363 1 5.50
CHEMBL1269530 1 5.47
CHEMBL4473228 1 5.43
CHEMBL4538732 1 5.38
CHEMBL1269529 1 5.35
CHEMBL4513636 1 5.33
CHEMBL4576062 1 5.33
CHEMBL4451254 1 5.30
CHEMBL4447776 1 5.24
CHEMBL4458590 1 5.20
CHEMBL4462882 1 5.04
CHEMBL4470629 1 5.02
CHEMBL4569132 1 4.84
CHEMBL4437528 1 4.71
CHEMBL4589332 1 4.41
CHEMBL4567922 1 -
CHEMBL4539657 1 -
CHEMBL4460669 1 -
CHEMBL4559535 1 -
CHEMBL230006 ENOXOLONE 2.0 1 -
CHEMBL4450596 1 -
CHEMBL4561233 1 -
CHEMBL4438222 1 -
CHEMBL4453165 1 -
CHEMBL4459420 1 -
CHEMBL4561996 1 -
CHEMBL4472451 1 -
CHEMBL4469384 1 -
CHEMBL4456956 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4451839 IC50 = 2528.0 nM 5.60
CHEMBL4559363 IC50 = 3171.0 nM 5.50
CHEMBL1269530 IC50 = 3398.0 nM 5.47
CHEMBL4473228 IC50 = 3749.0 nM 5.43
CHEMBL4538732 IC50 = 4127.0 nM 5.38
CHEMBL1269529 IC50 = 4431.0 nM 5.35
CHEMBL4513636 IC50 = 4645.0 nM 5.33
CHEMBL4576062 IC50 = 4645.0 nM 5.33
CHEMBL4451254 IC50 = 5024.0 nM 5.30
CHEMBL4447776 IC50 = 5765.0 nM 5.24
CHEMBL4458590 IC50 = 6247.0 nM 5.20
CHEMBL4462882 IC50 = 9011.0 nM 5.04
CHEMBL4470629 IC50 = 9630.0 nM 5.02
CHEMBL4569132 IC50 = 14410.0 nM 4.84
CHEMBL4437528 IC50 = 19330.0 nM 4.71
CHEMBL4589332 IC50 = 39250.0 nM 4.41
CHEMBL4462419 IC50 > 40000.0 nM -
CHEMBL4583667 IC50 > 40000.0 nM -
CHEMBL4583971 IC50 > 40000.0 nM -
CHEMBL4456956 IC50 > 40000.0 nM -
CHEMBL4469384 IC50 > 40000.0 nM -
CHEMBL4472451 IC50 > 40000.0 nM -
CHEMBL4561996 IC50 > 40000.0 nM -
CHEMBL4459420 IC50 > 40000.0 nM -
CHEMBL4453165 IC50 > 40000.0 nM -
CHEMBL4438222 IC50 > 40000.0 nM -
CHEMBL4561233 IC50 > 40000.0 nM -
CHEMBL4450596 IC50 > 40000.0 nM -
CHEMBL230006 ENOXOLONE IC50 > 40000.0 nM -
CHEMBL4559535 IC50 > 40000.0 nM -
CHEMBL4460669 IC50 > 40000.0 nM -
CHEMBL4539657 IC50 > 40000.0 nM -
CHEMBL4567922 IC50 > 40000.0 nM -