Assay Detail
Functional
CHEMBL4367026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU145 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.20 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 10.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.94 |
| CHEMBL4550982 | — | — | 1 | 7.86 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.45 |
| CHEMBL4591755 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL4550982 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL107 | COLCHICINE | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL4591755 | — | IC50 | = | 169.1 | nM | 6.77 |