Assay Detail
Binding
CHEMBL4367996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-citalopram from SERT in rat cortex tissue incubated for 60 mins by microbeta scintillation counting method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT<sub>1A</sub> receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.03 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4469537 | — | — | 1 | 8.10 |
| CHEMBL4582567 | — | — | 1 | 7.82 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.54 |
| CHEMBL4467024 | — | — | 1 | 7.54 |
| CHEMBL4469633 | — | — | 1 | 7.51 |
| CHEMBL4455658 | — | — | 1 | 7.47 |
| CHEMBL4471395 | — | — | 1 | 7.28 |
| CHEMBL4471755 | — | — | 1 | 7.23 |
| CHEMBL4449982 | — | — | 1 | 7.22 |
| CHEMBL4476164 | — | — | 1 | 7.15 |
| CHEMBL4543669 | — | — | 1 | 7.14 |
| CHEMBL4444099 | — | — | 1 | 7.11 |
| CHEMBL4470437 | — | — | 1 | 7.06 |
| CHEMBL4458712 | — | — | 1 | 7.01 |
| CHEMBL4475730 | — | — | 1 | 6.98 |
| CHEMBL4515025 | — | — | 1 | 6.96 |
| CHEMBL4530671 | — | — | 1 | 6.93 |
| CHEMBL4472972 | — | — | 1 | 6.88 |
| CHEMBL4442394 | — | — | 1 | 6.88 |
| CHEMBL4533362 | — | — | 1 | 6.84 |
| CHEMBL4458537 | — | — | 1 | 6.82 |
| CHEMBL4545518 | — | — | 1 | 6.67 |
| CHEMBL4466243 | — | — | 1 | 6.62 |
| CHEMBL4462825 | — | — | 1 | 6.60 |
| CHEMBL4531647 | — | — | 1 | 6.52 |
| CHEMBL4464118 | — | — | 1 | 6.51 |
| CHEMBL4460224 | — | — | 1 | 6.22 |
| CHEMBL4465006 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4469537 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4582567 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4467024 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4469633 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4455658 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4471395 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL4471755 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL4449982 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL4476164 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL4543669 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL4444099 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL4470437 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL4458712 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL4475730 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL4515025 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL4530671 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL4472972 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL4442394 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL4533362 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL4458537 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL4545518 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL4466243 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4462825 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL4531647 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL4464118 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL4460224 | — | Ki | = | 607.0 | nM | 6.22 |
| CHEMBL4465006 | — | Ki | = | 602.0 | nM | 6.22 |