Assay Detail
Binding
CHEMBL4368255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-5 receptor in mouse pro-B Y16 cells assessed as decrease in mIL-5 dependent cell proliferation after 48 hrs in presence of 3 units/ml mIL-5 by WST-1 assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-5 receptor subunit alpha (CHEMBL4523198) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.80 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463994 | — | — | 1 | 5.46 |
| CHEMBL4586328 | — | — | 1 | 5.30 |
| CHEMBL4581146 | — | — | 1 | 5.12 |
| CHEMBL486626 | SOPHORICOSIDE | — | 1 | 4.97 |
| CHEMBL4562876 | — | — | 1 | 4.92 |
| CHEMBL4445471 | — | — | 1 | 4.89 |
| CHEMBL4438982 | — | — | 1 | 4.72 |
| CHEMBL4475617 | — | — | 1 | 4.70 |
| CHEMBL4534125 | — | — | 1 | 4.70 |
| CHEMBL4459407 | — | — | 1 | 4.70 |
| CHEMBL4572156 | — | — | 1 | 4.68 |
| CHEMBL4532376 | — | — | 1 | 4.66 |
| CHEMBL4572499 | — | — | 1 | 4.60 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 4.58 |
| CHEMBL4530753 | — | — | 1 | 4.56 |
| CHEMBL4442984 | — | — | 1 | 4.54 |
| CHEMBL4463959 | — | — | 1 | 4.52 |
| CHEMBL4464998 | — | — | 1 | - |
| CHEMBL4556260 | — | — | 1 | - |
| CHEMBL4513551 | — | — | 1 | - |
| CHEMBL4577331 | — | — | 1 | - |
| CHEMBL4533564 | — | — | 1 | - |
| CHEMBL4581975 | — | — | 1 | - |
| CHEMBL4567563 | — | — | 1 | - |
| CHEMBL4589768 | — | — | 1 | - |
| CHEMBL4469649 | — | — | 1 | - |
| CHEMBL4440415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463994 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4586328 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4581146 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL486626 | SOPHORICOSIDE | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4562876 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4445471 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4438982 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4475617 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4534125 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4459407 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4572156 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4532376 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4572499 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4530753 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL4442984 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4463959 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4464998 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4556260 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4513551 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4577331 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4533564 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4581975 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4567563 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4589768 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4469649 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4440415 | — | IC50 | > | 30000.0 | nM | - |