Assay Detail
Binding
CHEMBL4369944
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Inhibition of sigma receptor 1 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and in Vivo Characterization of A<sub>1</sub> Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.89 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541086 | — | — | 1 | 6.32 |
| CHEMBL4436917 | — | — | 1 | 6.20 |
| CHEMBL4439013 | — | — | 1 | 6.16 |
| CHEMBL595547 | 5'-CARBOXY ADENOSINE | — | 1 | 5.83 |
| CHEMBL4554295 | — | — | 1 | 5.82 |
| CHEMBL4436786 | — | — | 1 | 5.75 |
| CHEMBL4543137 | — | — | 1 | 5.71 |
| CHEMBL2170801 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541086 | — | Ki | = | 484.0 | nM | 6.32 |
| CHEMBL4436917 | — | Ki | = | 626.0 | nM | 6.20 |
| CHEMBL4439013 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL595547 | 5'-CARBOXY ADENOSINE | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL4554295 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4436786 | — | Ki | = | 1790.0 | nM | 5.75 |
| CHEMBL4543137 | — | Ki | = | 1970.0 | nM | 5.71 |
| CHEMBL2170801 | — | Ki | = | 5090.0 | nM | 5.29 |