Assay Detail
Binding
CHEMBL4370451
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Inhibition of 20S immunoproteasome beta 5 in human Raji cell lysates after 1 hr by competitive ABPP assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Subcellular | Lysate |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.48 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577205 | — | — | 1 | 7.34 |
| CHEMBL2326533 | — | — | 1 | 5.93 |
| CHEMBL4590398 | — | — | 1 | 5.68 |
| CHEMBL4440581 | — | — | 1 | 5.66 |
| CHEMBL4451682 | — | — | 1 | 5.55 |
| CHEMBL4546121 | — | — | 1 | 4.90 |
| CHEMBL4513509 | — | — | 1 | 4.55 |
| CHEMBL4545073 | — | — | 1 | 4.24 |
| CHEMBL4443899 | — | — | 1 | - |
| CHEMBL4544868 | — | — | 1 | - |
| CHEMBL4550552 | — | — | 1 | - |
| CHEMBL4518685 | — | — | 1 | - |
| CHEMBL4452605 | — | — | 1 | - |
| CHEMBL4592602 | — | — | 1 | - |
| CHEMBL4446214 | — | — | 1 | - |
| CHEMBL4442929 | — | — | 1 | - |
| CHEMBL4450505 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577205 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2326533 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4590398 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4440581 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4451682 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4546121 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4513509 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL4545073 | — | IC50 | = | 57100.0 | nM | 4.24 |
| CHEMBL4443899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4544868 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4550552 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4518685 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4452605 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4592602 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4446214 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4442929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4450505 | — | IC50 | > | 100000.0 | nM | - |