Assay Detail
Binding
CHEMBL4371162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.89 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360390 | — | — | 1 | 9.52 |
| CHEMBL189709 | — | — | 1 | 9.40 |
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.30 |
| CHEMBL188799 | — | — | 1 | 9.22 |
| CHEMBL186655 | — | — | 1 | 9.00 |
| CHEMBL188798 | — | — | 1 | 9.00 |
| CHEMBL364610 | — | — | 1 | 8.00 |
| CHEMBL360407 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360390 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL189709 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL439849 | VILAZODONE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL188799 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL186655 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL188798 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL364610 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL360407 | — | IC50 | = | 20.0 | nM | 7.70 |