Assay Detail
ADMET
CHEMBL4371971
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Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured after 10 mins by LC-MS/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.62 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4593464 | — | — | 1 | 8.62 |
| CHEMBL4557596 | — | — | 1 | - |
| CHEMBL4474161 | — | — | 1 | - |
| CHEMBL4438972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4593464 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4557596 | — | IC50 | > | 12.5 | nM | - |
| CHEMBL4474161 | — | IC50 | > | 12.5 | nM | - |
| CHEMBL4438972 | — | IC50 | > | 12.5 | nM | - |