Assay Detail
Binding
CHEMBL4373082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis of novel purin-6-one derivatives as phosphodiesterase 2 (PDE2) inhibitors: The neuroprotective and anxiolytic-like effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.72 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370962 | — | — | 1 | 8.32 |
| CHEMBL4580973 | — | — | 1 | 7.14 |
| CHEMBL4591047 | — | — | 1 | 7.09 |
| CHEMBL4453746 | — | — | 1 | 6.51 |
| CHEMBL4458207 | — | — | 1 | 6.24 |
| CHEMBL4437158 | — | — | 1 | 5.91 |
| CHEMBL4448676 | — | — | 1 | 5.71 |
| CHEMBL4458316 | — | — | 1 | 5.58 |
| CHEMBL4578464 | — | — | 1 | 5.42 |
| CHEMBL4518682 | — | — | 1 | 5.41 |
| CHEMBL4443594 | — | — | 1 | 5.40 |
| CHEMBL4516467 | — | — | 1 | 5.37 |
| CHEMBL4533780 | — | — | 1 | 5.37 |
| CHEMBL4453022 | — | — | 1 | 5.26 |
| CHEMBL4539824 | — | — | 1 | 5.24 |
| CHEMBL4473227 | — | — | 1 | 5.23 |
| CHEMBL4467295 | — | — | 1 | 5.14 |
| CHEMBL4446592 | — | — | 1 | 4.96 |
| CHEMBL4562875 | — | — | 1 | 4.77 |
| CHEMBL4463360 | — | — | 1 | 4.39 |
| CHEMBL4569293 | — | — | 1 | - |
| CHEMBL4475675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370962 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4580973 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4591047 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4453746 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4458207 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4437158 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4448676 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4458316 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL4578464 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL4518682 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL4443594 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL4516467 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL4533780 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL4453022 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL4539824 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4473227 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL4467295 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL4446592 | — | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL4562875 | — | IC50 | = | 16980.0 | nM | 4.77 |
| CHEMBL4463360 | — | IC50 | = | 40350.0 | nM | 4.39 |
| CHEMBL4569293 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4475675 | — | IC50 | > | 50000.0 | nM | - |