Assay Detail
Binding
CHEMBL4380084
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Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cell membranes incubated for 60 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.58 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 9.39 |
| CHEMBL61630 | — | — | 1 | 8.14 |
| CHEMBL4546925 | — | — | 1 | 7.26 |
| CHEMBL292521 | — | — | 1 | 6.98 |
| CHEMBL60533 | CORYNANRHEIDINE | — | 1 | 6.93 |
| CHEMBL299031 | — | — | 1 | 6.79 |
| CHEMBL31421 | — | — | 1 | - |
| CHEMBL290543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL61630 | — | Ki | = | 7.16 | nM | 8.14 |
| CHEMBL4546925 | — | Ki | = | 54.5 | nM | 7.26 |
| CHEMBL292521 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL60533 | CORYNANRHEIDINE | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL299031 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL31421 | — | Ki | - | — | - | |
| CHEMBL290543 | — | Ki | - | — | - |