Assay Detail
Functional
CHEMBL4380091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant mu opioid receptor expressed in CHO cells assessed as stimulation of cAMP accumulation incubated for 10 mins by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.35 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61630 | — | — | 1 | 8.12 |
| CHEMBL4546925 | — | — | 1 | 7.41 |
| CHEMBL299031 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61630 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4546925 | — | EC50 | = | 39.2 | nM | 7.41 |
| CHEMBL299031 | — | EC50 | = | 307.5 | nM | 6.51 |