Assay Detail
Binding
CHEMBL4380186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type human SERT expressed in HEK293 cells assessed as inhibition of [3H]-5HT reuptake preincubated for 5 mins followed by [3H]5HT addition and measured after 1 min by liquid scintillation counting analysis
71
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 4.46 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4461596 | — | — | 1 | 4.61 |
| CHEMBL4438894 | — | — | 1 | 4.53 |
| CHEMBL4473574 | — | — | 1 | 4.23 |
| CHEMBL4588349 | — | — | 1 | - |
| CHEMBL4453674 | — | — | 1 | - |
| CHEMBL4517473 | — | — | 1 | - |
| CHEMBL4458656 | — | — | 1 | - |
| CHEMBL4446076 | — | — | 1 | - |
| CHEMBL4560378 | — | — | 1 | - |
| CHEMBL4470394 | — | — | 1 | - |
| CHEMBL4568351 | — | — | 1 | - |
| CHEMBL4455022 | — | — | 1 | - |
| CHEMBL1201192 | ARMODAFINIL | 4.0 | 1 | - |
| CHEMBL4437729 | — | — | 1 | - |
| CHEMBL4439598 | — | — | 1 | - |
| CHEMBL4466223 | — | — | 1 | - |
| CHEMBL4470744 | — | — | 1 | - |
| CHEMBL4437004 | — | — | 1 | - |
| CHEMBL4569016 | — | — | 1 | - |
| CHEMBL4459806 | — | — | 1 | - |
| CHEMBL4475690 | — | — | 1 | - |
| CHEMBL4451429 | — | — | 1 | - |
| CHEMBL4436791 | — | — | 1 | - |
| CHEMBL4441345 | — | — | 1 | - |
| CHEMBL4583781 | — | — | 1 | - |
| CHEMBL4539793 | — | — | 1 | - |
| CHEMBL4443822 | — | — | 1 | - |
| CHEMBL4562715 | — | — | 1 | - |
| CHEMBL4593487 | — | — | 1 | - |
| CHEMBL4454714 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4461596 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4438894 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL4473574 | — | IC50 | = | 58650.0 | nM | 4.23 |
| CHEMBL4458656 | — | IC50 | - | — | - | |
| CHEMBL4444833 | — | IC50 | - | — | - | |
| CHEMBL4439598 | — | IC50 | = | 436100.0 | nM | - |
| CHEMBL4437729 | — | IC50 | - | — | - | |
| CHEMBL4588349 | — | IC50 | - | — | - | |
| CHEMBL4536039 | — | IC50 | - | — | - | |
| CHEMBL4437734 | — | IC50 | - | — | - | |
| CHEMBL4453638 | — | IC50 | - | — | - | |
| CHEMBL4466697 | — | IC50 | - | — | - | |
| CHEMBL4541596 | — | IC50 | = | 200800.0 | nM | - |
| CHEMBL4579575 | — | IC50 | - | — | - | |
| CHEMBL4464920 | — | IC50 | - | — | - | |
| CHEMBL4552525 | — | IC50 | - | — | - | |
| CHEMBL4456526 | — | IC50 | = | 201500.0 | nM | - |
| CHEMBL4453763 | — | IC50 | - | — | - | |
| CHEMBL4464187 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL4459947 | — | IC50 | - | — | - | |
| CHEMBL4587340 | — | IC50 | - | — | - | |
| CHEMBL4469951 | — | IC50 | - | — | - | |
| CHEMBL4449011 | — | IC50 | - | — | - | |
| CHEMBL4526999 | — | IC50 | - | — | - | |
| CHEMBL4542611 | — | IC50 | - | — | - | |
| CHEMBL4542509 | — | IC50 | - | — | - | |
| CHEMBL4569016 | — | IC50 | - | — | - | |
| CHEMBL4454714 | — | IC50 | - | — | - | |
| CHEMBL4593487 | — | IC50 | - | — | - | |
| CHEMBL4562715 | — | IC50 | - | — | - | |
| CHEMBL4443822 | — | IC50 | - | — | - | |
| CHEMBL4539793 | — | IC50 | - | — | - | |
| CHEMBL4583781 | — | IC50 | - | — | - | |
| CHEMBL4441345 | — | IC50 | - | — | - | |
| CHEMBL4436791 | — | IC50 | - | — | - | |
| CHEMBL4453674 | — | IC50 | - | — | - | |
| CHEMBL4475690 | — | IC50 | - | — | - | |
| CHEMBL4459806 | — | IC50 | - | — | - | |
| CHEMBL4446076 | — | IC50 | - | — | - | |
| CHEMBL4437004 | — | IC50 | - | — | - | |
| CHEMBL4470744 | — | IC50 | - | — | - | |
| CHEMBL4466223 | — | IC50 | - | — | - | |
| CHEMBL4451429 | — | IC50 | - | — | - | |
| CHEMBL4517473 | — | IC50 | - | — | - | |
| CHEMBL1201192 | ARMODAFINIL | IC50 | = | 232000.0 | nM | - |
| CHEMBL4455022 | — | IC50 | - | — | - | |
| CHEMBL4568351 | — | IC50 | = | 220900.0 | nM | - |
| CHEMBL4470394 | — | IC50 | - | — | - | |
| CHEMBL4444833 | — | IC50 | - | — | - | |
| CHEMBL4560378 | — | IC50 | - | — | - |