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Assay Detail

CHEMBL4384228

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Functional
Antiparasitic activity against Giardia lamblia WB trophozoites after 24 to 48 hrs by CellTiter-Glo luminescent cell viability assay
ChEMBL ↗
117
Total Activities
67
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Giardia intestinalis
Confidence 1 — Organism
Curated By Autocuration

Target

Giardia intestinalis (CHEMBL612652) ↗
Type ORGANISM
Organism Giardia intestinalis

Publication

Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.
Jarrad AM, Ang CW, Debnath A, Hahn HJ, Woods K, Tan L, Sykes ML, Jones AJ, Pelingon R, Butler MS, Avery VM, West NP, Karoli T, Blaskovich MAT, Cooper MA.
J Med Chem (2018) 61 : 11349 -11371
PubMed 30468386 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 115 5.27 6.70
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3940020 — — 1 6.70
CHEMBL4460588 — — 1 6.70
CHEMBL3983955 — — 1 6.70
CHEMBL3956327 — — 1 6.70
CHEMBL4435915 — — 1 6.70
CHEMBL4469243 — — 2 5.80
CHEMBL4473101 — — 2 5.80
CHEMBL4472888 — — 2 5.80
CHEMBL4468508 — — 2 5.72
CHEMBL4522285 — — 2 5.70
CHEMBL4563622 — — 2 5.60
CHEMBL3956589 — — 1 5.57
CHEMBL3920140 — — 1 5.57
CHEMBL3985906 — — 1 5.57
CHEMBL3957229 — — 1 5.57
CHEMBL3947931 — — 1 5.57
CHEMBL227875 PRETOMANID 4.0 2 5.52
CHEMBL4530876 — — 2 5.50
CHEMBL4457433 — — 2 5.50
CHEMBL4580019 — — 2 5.50
CHEMBL512244 — — 2 5.50
CHEMBL4444662 — — 2 5.50
CHEMBL4516883 — — 2 5.41
CHEMBL4580469 — — 2 5.40
CHEMBL4579641 — — 2 5.40
CHEMBL4549044 — — 2 5.30
CHEMBL4435234 — — 2 5.30
CHEMBL4453745 — — 2 5.30
CHEMBL4453399 — — 2 5.30
CHEMBL4562001 — — 2 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3983955 — IC50 = 200.0 nM 6.70
CHEMBL4435915 — IC50 = 200.0 nM 6.70
CHEMBL3940020 — IC50 = 200.0 nM 6.70
CHEMBL4460588 — IC50 = 200.0 nM 6.70
CHEMBL3956327 — IC50 = 200.0 nM 6.70
CHEMBL4469243 — IC50 = 1584.89 nM 5.80
CHEMBL4472888 — IC50 = 1584.89 nM 5.80
CHEMBL4472888 — IC50 = 1600.0 nM 5.80
CHEMBL4473101 — IC50 = 1584.89 nM 5.80
CHEMBL4469243 — IC50 = 1700.0 nM 5.77
CHEMBL4473101 — IC50 = 1700.0 nM 5.77
CHEMBL4468508 — IC50 = 1900.0 nM 5.72
CHEMBL4522285 — IC50 = 1995.26 nM 5.70
CHEMBL4468508 — IC50 = 1995.26 nM 5.70
CHEMBL4522285 — IC50 = 2100.0 nM 5.68
CHEMBL4563622 — IC50 = 2511.89 nM 5.60
CHEMBL3956589 — IC50 = 2700.0 nM 5.57
CHEMBL3920140 — IC50 = 2700.0 nM 5.57
CHEMBL3947931 — IC50 = 2700.0 nM 5.57
CHEMBL3985906 — IC50 = 2700.0 nM 5.57
CHEMBL3957229 — IC50 = 2700.0 nM 5.57
CHEMBL4563622 — IC50 = 2800.0 nM 5.55
CHEMBL227875 PRETOMANID IC50 = 3000.0 nM 5.52
CHEMBL4530876 — IC50 = 3162.28 nM 5.50
CHEMBL512244 — IC50 = 3200.0 nM 5.50
CHEMBL227875 PRETOMANID IC50 = 3162.28 nM 5.50
CHEMBL4444662 — IC50 = 3162.28 nM 5.50
CHEMBL512244 — IC50 = 3162.28 nM 5.50
CHEMBL4580019 — IC50 = 3162.28 nM 5.50
CHEMBL4457433 — IC50 = 3162.28 nM 5.50
CHEMBL4444662 — IC50 = 3200.0 nM 5.50
CHEMBL4530876 — IC50 = 3300.0 nM 5.48
CHEMBL4457433 — IC50 = 3400.0 nM 5.47
CHEMBL4580019 — IC50 = 3500.0 nM 5.46
CHEMBL4516883 — IC50 = 3900.0 nM 5.41
CHEMBL4579641 — IC50 = 3981.07 nM 5.40
CHEMBL4580469 — IC50 = 3981.07 nM 5.40
CHEMBL4516883 — IC50 = 3981.07 nM 5.40
CHEMBL4580469 — IC50 = 4200.0 nM 5.38
CHEMBL4579641 — IC50 = 4400.0 nM 5.36
CHEMBL4453745 — IC50 = 5011.87 nM 5.30
CHEMBL4453399 — IC50 = 5011.87 nM 5.30
CHEMBL4562001 — IC50 = 5011.87 nM 5.30
CHEMBL4565179 — IC50 = 5011.87 nM 5.30
CHEMBL4453399 — IC50 = 5000.0 nM 5.30
CHEMBL4549044 — IC50 = 5011.87 nM 5.30
CHEMBL4435234 — IC50 = 5011.87 nM 5.30
CHEMBL4453745 — IC50 = 5300.0 nM 5.28
CHEMBL4435234 — IC50 = 5200.0 nM 5.28
CHEMBL4549044 — IC50 = 5200.0 nM 5.28