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Compound Detail

CHEMBL4565179

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O=[N+]([O-])c1cn2ccnc(OCCc3ccc(OC(F)(F)F)cc3)c2n1

Basic Information

ChEMBL ID CHEMBL4565179
Phase Preclinical
Structure Type MOL
InChI Key BMSAOVLFLYMJON-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names

Molecular Properties

368.3
MW (Da)
3.16
ALogP
7
HBA
0
HBD
91.8
PSA (Ų)
0.49
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H11F3N4O4
MW 368.27
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -1.55

Activity Summary

IC50 3 meas. best 5.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 5.3 5.29 5011.9 2
Entamoeba histolytica
CHEMBL612853
IC50 5.11 5.11 7800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30468386 10.1021/acs.jmedchem.8b01578 Giardia intestinalis 2
30468386 10.1021/acs.jmedchem.8b01578 Mycobacterium tuberculosis 2
30468386 10.1021/acs.jmedchem.8b01578 Trypanosoma brucei brucei 1
30468386 10.1021/acs.jmedchem.8b01578 Entamoeba histolytica 1
30468386 10.1021/acs.jmedchem.8b01578 Staphylococcus aureus 1
30468386 10.1021/acs.jmedchem.8b01578 Escherichia coli 1
30468386 10.1021/acs.jmedchem.8b01578 Klebsiella pneumoniae 1
30468386 10.1021/acs.jmedchem.8b01578 Acinetobacter baumannii 1
30468386 10.1021/acs.jmedchem.8b01578 Pseudomonas aeruginosa 1
30468386 10.1021/acs.jmedchem.8b01578 Candida albicans 1
30468386 10.1021/acs.jmedchem.8b01578 Cryptococcus neoformans 1
30468386 10.1021/acs.jmedchem.8b01578 HEK293 1
30468386 10.1021/acs.jmedchem.8b01578 HepG2 1
- 10.6019/CHEMBL4513134 HEK293 1

Data from ChEMBL 36 via Core Engine