Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4384229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 24 to 48 hrs by CellTiter-Glo luminescent cell viability assay
ChEMBL ↗
77
Total Activities
50
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Entamoeba histolytica
Confidence 1 — Organism
Curated By Autocuration

Target

Entamoeba histolytica (CHEMBL612853) ↗
Type ORGANISM
Organism Entamoeba histolytica

Publication

Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.
Jarrad AM, Ang CW, Debnath A, Hahn HJ, Woods K, Tan L, Sykes ML, Jones AJ, Pelingon R, Butler MS, Avery VM, West NP, Karoli T, Blaskovich MAT, Cooper MA.
J Med Chem (2018) 61 : 11349 -11371
PubMed 30468386 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 75 4.98 5.66
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3983955 — — 1 5.66
CHEMBL4460588 — — 1 5.66
CHEMBL3940020 — — 1 5.66
CHEMBL4435915 — — 1 5.66
CHEMBL3956327 — — 1 5.66
CHEMBL137 METRONIDAZOLE 4.0 2 5.40
CHEMBL512244 — — 2 5.30
CHEMBL4565179 — — 1 5.11
CHEMBL4530876 — — 2 5.04
CHEMBL227875 PRETOMANID 4.0 2 5.03
CHEMBL4459697 — — 2 5.02
CHEMBL3956589 — — 1 5.00
CHEMBL4580469 — — 2 5.00
CHEMBL4579641 — — 2 5.00
CHEMBL3920140 — — 1 5.00
CHEMBL3957229 — — 1 5.00
CHEMBL3985906 — — 1 5.00
CHEMBL3947931 — — 1 5.00
CHEMBL4469243 — — 2 4.82
CHEMBL4563622 — — 2 4.80
CHEMBL4447641 — — 2 4.80
CHEMBL4453745 — — 2 4.75
CHEMBL4516883 — — 2 4.60
CHEMBL4453184 — — 2 4.52
CHEMBL4453153 — — 2 4.50
CHEMBL4435234 — — 2 4.50
CHEMBL4548055 — — 1 -
CHEMBL4562001 — — 2 -
CHEMBL4557266 — — 2 -
CHEMBL4468508 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3983955 — IC50 = 2200.0 nM 5.66
CHEMBL3956327 — IC50 = 2200.0 nM 5.66
CHEMBL4435915 — IC50 = 2200.0 nM 5.66
CHEMBL4460588 — IC50 = 2200.0 nM 5.66
CHEMBL3940020 — IC50 = 2200.0 nM 5.66
CHEMBL137 METRONIDAZOLE IC50 = 3981.07 nM 5.40
CHEMBL137 METRONIDAZOLE IC50 = 4300.0 nM 5.37
CHEMBL512244 — IC50 = 5011.87 nM 5.30
CHEMBL512244 — IC50 = 5300.0 nM 5.28
CHEMBL4565179 — IC50 = 7800.0 nM 5.11
CHEMBL4530876 — IC50 = 9100.0 nM 5.04
CHEMBL227875 PRETOMANID IC50 = 9300.0 nM 5.03
CHEMBL4459697 — IC50 = 9500.0 nM 5.02
CHEMBL4580469 — IC50 = 10000.0 nM 5.00
CHEMBL3957229 — IC50 = 10000.0 nM 5.00
CHEMBL3985906 — IC50 = 10000.0 nM 5.00
CHEMBL3947931 — IC50 = 10000.0 nM 5.00
CHEMBL3920140 — IC50 = 10000.0 nM 5.00
CHEMBL3956589 — IC50 = 10000.0 nM 5.00
CHEMBL4579641 — IC50 = 10000.0 nM 5.00
CHEMBL4579641 — IC50 = 10000.0 nM 5.00
CHEMBL4530876 — IC50 = 10000.0 nM 5.00
CHEMBL227875 PRETOMANID IC50 = 10000.0 nM 5.00
CHEMBL4580469 — IC50 = 10000.0 nM 5.00
CHEMBL4459697 — IC50 = 10000.0 nM 5.00
CHEMBL4469243 — IC50 = 15000.0 nM 4.82
CHEMBL4563622 — IC50 = 15848.93 nM 4.80
CHEMBL4447641 — IC50 = 15848.93 nM 4.80
CHEMBL4469243 — IC50 = 15848.93 nM 4.80
CHEMBL4563622 — IC50 = 16000.0 nM 4.80
CHEMBL4447641 — IC50 = 17000.0 nM 4.77
CHEMBL4453745 — IC50 = 18000.0 nM 4.75
CHEMBL4453745 — IC50 = 19952.62 nM 4.70
CHEMBL4516883 — IC50 = 25118.86 nM 4.60
CHEMBL4516883 — IC50 = 27000.0 nM 4.57
CHEMBL4453184 — IC50 = 30000.0 nM 4.52
CHEMBL4453153 — IC50 = 31622.78 nM 4.50
CHEMBL4435234 — IC50 = 31622.78 nM 4.50
CHEMBL4453184 — IC50 = 31622.78 nM 4.50
CHEMBL4435234 — IC50 = 33000.0 nM 4.48
CHEMBL4453153 — IC50 = 34000.0 nM 4.47
CHEMBL4460422 — Activity - — -
CHEMBL3912869 — IC50 > 25000.0 nM -
CHEMBL4473101 — IC50 > 50000.0 nM -
CHEMBL4565041 — Activity - — -
CHEMBL4527225 — IC50 > 50000.0 nM -
CHEMBL4527225 — IC50 > 50118.72 nM -
CHEMBL4453399 — IC50 > 50000.0 nM -
CHEMBL4467771 — IC50 > 25000.0 nM -
CHEMBL4580019 — IC50 > 50000.0 nM -