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Compound Detail

CHEMBL4447641

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Cc1nc(OCc2ccc(OC(F)(F)F)cc2)c2nc([N+](=O)[O-])cn2c1C

Basic Information

ChEMBL ID CHEMBL4447641
Phase Preclinical
Structure Type MOL
InChI Key QDUFGNHEMWBENM-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

382.3
MW (Da)
3.73
ALogP
7
HBA
0
HBD
91.8
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H13F3N4O4
MW 382.30
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.34

Activity Summary

IC50 6 meas. best 5.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 5.1 5.085 7943.3 2
Trypanosoma brucei brucei
CHEMBL612851
IC50 5.0 5.0 10000.0 2
Entamoeba histolytica
CHEMBL612853
IC50 4.8 4.785 15848.9 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30468386 10.1021/acs.jmedchem.8b01578 ADMET 5
36111399 10.1021/acs.jmedchem.2c00972 Mycobacterium tuberculosis 3
36111399 10.1021/acs.jmedchem.2c00972 Unchecked 3
30468386 10.1021/acs.jmedchem.8b01578 Giardia intestinalis 2
30468386 10.1021/acs.jmedchem.8b01578 Entamoeba histolytica 2
30468386 10.1021/acs.jmedchem.8b01578 Mycobacterium tuberculosis 2
30468386 10.1021/acs.jmedchem.8b01578 Trypanosoma brucei brucei 2
- 10.6019/CHEMBL4513134 HEK293 1
36111399 10.1021/acs.jmedchem.2c00972 Mycobacterium avium 1
36111399 10.1021/acs.jmedchem.2c00972 Mycolicibacterium smegmatis 1

Data from ChEMBL 36 via Core Engine