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Compound Detail

CHEMBL4548055

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O=c1c2nc([N+](=O)[O-])cn2ccn1Cc1ccc(F)cc1

Basic Information

ChEMBL ID CHEMBL4548055
Phase Preclinical
Structure Type MOL
InChI Key NBFYZKFNSBBCIM-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names

Molecular Properties

288.2
MW (Da)
1.59
ALogP
6
HBA
0
HBD
82.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H9FN4O3
MW 288.24
Aromatic Rings 3
Heavy Atoms 21
NP-Likeness -1.81

Activity Summary

IC50 4 meas. best 5.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trypanosoma brucei brucei
CHEMBL612851
IC50 5.54 5.52 2900.0 2
Giardia intestinalis
CHEMBL612652
IC50 5.2 5.195 6309.6 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30468386 10.1021/acs.jmedchem.8b01578 ADMET 5
30468386 10.1021/acs.jmedchem.8b01578 Trypanosoma brucei brucei 2
30468386 10.1021/acs.jmedchem.8b01578 Giardia intestinalis 2
30468386 10.1021/acs.jmedchem.8b01578 Mycobacterium tuberculosis 2
30468386 10.1021/acs.jmedchem.8b01578 Entamoeba histolytica 1
30468386 10.1021/acs.jmedchem.8b01578 Clostridioides difficile 1
30468386 10.1021/acs.jmedchem.8b01578 Staphylococcus aureus 1
30468386 10.1021/acs.jmedchem.8b01578 Escherichia coli 1
30468386 10.1021/acs.jmedchem.8b01578 Klebsiella pneumoniae 1
30468386 10.1021/acs.jmedchem.8b01578 Acinetobacter baumannii 1
30468386 10.1021/acs.jmedchem.8b01578 Pseudomonas aeruginosa 1
30468386 10.1021/acs.jmedchem.8b01578 Candida albicans 1
30468386 10.1021/acs.jmedchem.8b01578 Cryptococcus neoformans 1
30468386 10.1021/acs.jmedchem.8b01578 HEK293 1
30468386 10.1021/acs.jmedchem.8b01578 HepG2 1

Data from ChEMBL 36 via Core Engine