Assay Detail
Functional
CHEMBL4384441
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Growth inhibition of human NCI-H1975 cells after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.61 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440618 | — | — | 1 | 7.22 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.00 |
| CHEMBL4435699 | — | — | 1 | 6.16 |
| CHEMBL4526992 | — | — | 1 | 5.85 |
| CHEMBL4530170 | — | — | 1 | 5.68 |
| CHEMBL4562352 | — | — | 1 | 5.52 |
| CHEMBL4559217 | — | — | 1 | 5.50 |
| CHEMBL4439974 | — | — | 1 | 5.47 |
| CHEMBL4558356 | — | — | 1 | 5.44 |
| CHEMBL4521214 | — | — | 1 | 5.43 |
| CHEMBL4538707 | — | — | 1 | 5.21 |
| CHEMBL4572315 | — | — | 1 | 5.16 |
| CHEMBL4437599 | — | — | 1 | 5.08 |
| CHEMBL4556799 | — | — | 1 | 5.04 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.04 |
| CHEMBL4473375 | — | — | 1 | 5.01 |
| CHEMBL4449681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440618 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4435699 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4526992 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4530170 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4562352 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4559217 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4439974 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4558356 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4521214 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4538707 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4572315 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4437599 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4556799 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL939 | GEFITINIB | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4473375 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4449681 | — | IC50 | > | 10000.0 | nM | - |