Compound Detail
CHEMBL4558356
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Basic Information
| ChEMBL ID | CHEMBL4558356 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SUBVZPCNUYJADP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
485.9
MW (Da)
5.05
ALogP
9
HBA
1
HBD
99.1
PSA (Ų)
0.16
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
| NCI-H1975 CHEMBL614348 | IC50 | 5.44 | 5.44 | 3600.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 24.0 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 27.0 | nM | 7.57 | Inhibition of wild type EGFR autophosphorylation in human A549 cells by Western ... | 30472599 |
| NCI-H1975 | IC50 | = | 3600.0 | nM | 5.44 | Growth inhibition of human NCI-H1975 cells after 72 hrs by MTT assay | 30472599 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30472599 | 10.1016/j.ejmech.2018.11.029 | Epidermal growth factor receptor | 5 |
| 30472599 | 10.1016/j.ejmech.2018.11.029 | No relevant target | 2 |
| 30472599 | 10.1016/j.ejmech.2018.11.029 | NCI-H1975 | 1 |
Data from ChEMBL 36 via Core Engine