Assay Detail
ADMET
CHEMBL4384763
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Reversible inhibition of CYP3A4 (unknown origin) in presence of NADPH by vivid red substrate-based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.31 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456312 | — | — | 1 | 7.00 |
| CHEMBL4547537 | — | — | 1 | 6.52 |
| CHEMBL4461475 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456312 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4547537 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4461475 | — | IC50 | = | 4000.0 | nM | 5.40 |