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Assay Detail

CHEMBL4386828

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Jurkat cells incubated for 3 days by CellTiter-Glo luminescent assay
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway.
Chae HD, Cox N, Capolicchio S, Lee JW, Horikoshi N, Kam S, Ng AA, Edwards J, Butler TL, Chan J, Lee Y, Potter G, Capece MC, Liu CW, Wakatsuki S, Smith M, Sakamoto KM.
Bioorg Med Chem Lett (2019) 29 : 2307 -2315
PubMed 31253529 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 6.22 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4590901 — — 1 6.77
CHEMBL221919 — — 1 6.75
CHEMBL4447525 — — 1 6.64
CHEMBL4538858 — — 1 6.57
CHEMBL4456530 — — 1 6.57
CHEMBL2313117 — — 1 6.46
CHEMBL1448 NICLOSAMIDE 4.0 1 6.40
CHEMBL4453910 — — 1 6.38
CHEMBL4466161 — — 1 6.37
CHEMBL4437330 — — 1 6.37
CHEMBL536151 IMD-0354 1.0 1 6.32
CHEMBL3898128 — — 1 6.30
CHEMBL2313116 — — 1 6.30
CHEMBL4588810 — — 1 6.29
CHEMBL4589141 — — 1 6.28
CHEMBL4442930 — — 1 6.28
CHEMBL4587423 — — 1 6.27
CHEMBL4545071 — — 1 6.26
CHEMBL221918 — — 1 6.26
CHEMBL2338696 — — 1 6.24
CHEMBL2313109 — — 1 6.24
CHEMBL3397768 — — 1 6.21
CHEMBL4466997 — — 1 6.21
CHEMBL4467546 — — 1 6.17
CHEMBL2088008 — — 1 6.17
CHEMBL4456093 — — 1 6.17
CHEMBL4471043 — — 1 6.16
CHEMBL4529134 — — 1 6.16
CHEMBL4535677 — — 1 6.16
CHEMBL4434655 — — 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4590901 — IC50 = 170.0 nM 6.77
CHEMBL221919 — IC50 = 180.0 nM 6.75
CHEMBL4447525 — IC50 = 230.0 nM 6.64
CHEMBL4538858 — IC50 = 270.0 nM 6.57
CHEMBL4456530 — IC50 = 270.0 nM 6.57
CHEMBL2313117 — IC50 = 350.0 nM 6.46
CHEMBL1448 NICLOSAMIDE IC50 = 400.0 nM 6.40
CHEMBL4453910 — IC50 = 420.0 nM 6.38
CHEMBL4466161 — IC50 = 430.0 nM 6.37
CHEMBL4437330 — IC50 = 430.0 nM 6.37
CHEMBL536151 IMD-0354 IC50 = 480.0 nM 6.32
CHEMBL3898128 — IC50 = 500.0 nM 6.30
CHEMBL2313116 — IC50 = 500.0 nM 6.30
CHEMBL4588810 — IC50 = 510.0 nM 6.29
CHEMBL4442930 — IC50 = 530.0 nM 6.28
CHEMBL4589141 — IC50 = 530.0 nM 6.28
CHEMBL4587423 — IC50 = 540.0 nM 6.27
CHEMBL4545071 — IC50 = 550.0 nM 6.26
CHEMBL221918 — IC50 = 550.0 nM 6.26
CHEMBL2338696 — IC50 = 570.0 nM 6.24
CHEMBL2313109 — IC50 = 580.0 nM 6.24
CHEMBL3397768 — IC50 = 620.0 nM 6.21
CHEMBL4466997 — IC50 = 620.0 nM 6.21
CHEMBL4456093 — IC50 = 670.0 nM 6.17
CHEMBL4467546 — IC50 = 680.0 nM 6.17
CHEMBL2088008 — IC50 = 670.0 nM 6.17
CHEMBL4471043 — IC50 = 700.0 nM 6.16
CHEMBL4529134 — IC50 = 700.0 nM 6.16
CHEMBL4535677 — IC50 = 690.0 nM 6.16
CHEMBL4434655 — IC50 = 700.0 nM 6.16
CHEMBL4452120 — IC50 = 710.0 nM 6.15
CHEMBL2088014 — IC50 = 710.0 nM 6.15
CHEMBL4472957 — IC50 = 730.0 nM 6.14
CHEMBL4456314 — IC50 = 740.0 nM 6.13
CHEMBL4468315 — IC50 = 750.0 nM 6.12
CHEMBL4444499 — IC50 = 750.0 nM 6.12
CHEMBL4451144 — IC50 = 800.0 nM 6.10
CHEMBL4548075 — IC50 = 790.0 nM 6.10
CHEMBL4530693 — IC50 = 820.0 nM 6.09
CHEMBL4473104 — IC50 = 810.0 nM 6.09
CHEMBL4447437 — IC50 = 840.0 nM 6.08
CHEMBL2313111 — IC50 = 840.0 nM 6.08
CHEMBL4462360 — IC50 = 860.0 nM 6.07
CHEMBL4457728 — IC50 = 880.0 nM 6.06
CHEMBL4443869 — IC50 = 880.0 nM 6.06
CHEMBL4561813 — IC50 = 880.0 nM 6.06
CHEMBL3917212 — IC50 = 930.0 nM 6.03
CHEMBL4574740 — IC50 = 940.0 nM 6.03
CHEMBL4583939 — IC50 = 1160.0 nM 5.94
CHEMBL4438822 — IC50 = 1240.0 nM 5.91