Assay Detail
ADMET
CHEMBL4388231
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Growth inhibition of Trypanosoma brucei bloodstream forms measured after 72 hrs by resazurin-based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.96 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.42 |
| CHEMBL4549839 | — | — | 1 | 5.23 |
| CHEMBL4469761 | — | — | 1 | 5.16 |
| CHEMBL4462566 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4549839 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4469761 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4462566 | — | EC50 | = | 9700.0 | nM | 5.01 |