Assay Detail
ADMET
CHEMBL4388239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP2C9 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446494 | — | — | 1 | 5.00 |
| CHEMBL4581650 | — | — | 1 | 5.00 |
| CHEMBL4545398 | — | — | 1 | 5.00 |
| CHEMBL4564287 | — | — | 1 | 5.00 |
| CHEMBL4579215 | — | — | 1 | 5.00 |
| CHEMBL4549839 | — | — | 1 | - |
| CHEMBL4566383 | — | — | 1 | - |
| CHEMBL4583705 | — | — | 1 | - |
| CHEMBL4453795 | — | — | 1 | - |
| CHEMBL4456198 | — | — | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL4439011 | — | — | 1 | - |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | - |
| CHEMBL2386433 | — | — | 1 | - |
| CHEMBL4465714 | — | — | 1 | - |
| CHEMBL4468228 | — | — | 1 | - |
| CHEMBL4540341 | — | — | 1 | - |
| CHEMBL4552119 | — | — | 1 | - |
| CHEMBL4462566 | — | — | 1 | - |
| CHEMBL4452773 | — | — | 1 | - |
| CHEMBL4444333 | — | — | 1 | - |
| CHEMBL4528355 | — | — | 1 | - |
| CHEMBL4554707 | — | — | 1 | - |
| CHEMBL4435791 | — | — | 1 | - |
| CHEMBL4460492 | — | — | 1 | - |
| CHEMBL4582026 | — | — | 1 | - |
| CHEMBL4554726 | — | — | 1 | - |
| CHEMBL4452155 | — | — | 1 | - |
| CHEMBL4469761 | — | — | 1 | - |
| CHEMBL4561783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446494 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4581650 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4545398 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4564287 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4579215 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL744 | RILUZOLE | IC50 | > | 25000.0 | nM | - |
| CHEMBL97797 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2386433 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4465714 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4468228 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4540341 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4566383 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4592124 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL95463 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4475811 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4458858 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4577695 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4441552 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4562350 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL432942 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4440584 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4581441 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4464690 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4476655 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4444333 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4561783 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4469761 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4452155 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4554726 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4582026 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4460492 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4435791 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4554707 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4528355 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4439011 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4452773 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4462566 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4552119 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4549839 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4583705 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4453795 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4456198 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | IC50 | > | 25000.0 | nM | - |