Assay Detail
Binding
CHEMBL4390417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A receptor in rat cortical membranes incubated for 15 mins by liquid scintillation spectrometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.56 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83894 | FANANSERIN | 2.0 | 1 | 10.22 |
| CHEMBL83975 | — | — | 1 | 8.52 |
| CHEMBL82826 | — | — | 1 | 8.43 |
| CHEMBL83035 | — | — | 1 | 8.30 |
| CHEMBL83780 | — | — | 1 | 8.15 |
| CHEMBL415272 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83894 | FANANSERIN | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL83975 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL82826 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL83035 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL83780 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL415272 | — | Ki | = | 18.0 | nM | 7.75 |