Assay Detail
ADMET
CHEMBL4392492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ACAT1
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.90 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4557603 | — | — | 1 | 6.49 |
| CHEMBL4531443 | — | — | 1 | 6.31 |
| CHEMBL4458847 | — | — | 1 | 6.22 |
| CHEMBL4453443 | — | — | 1 | 6.03 |
| CHEMBL4585408 | — | — | 1 | 6.01 |
| CHEMBL4452940 | — | — | 1 | 6.01 |
| CHEMBL4574644 | — | — | 1 | 5.88 |
| CHEMBL4453601 | — | — | 1 | 5.87 |
| CHEMBL4472207 | — | — | 1 | 5.85 |
| CHEMBL4592144 | — | — | 1 | 5.79 |
| CHEMBL4461148 | — | — | 1 | 5.78 |
| CHEMBL4460750 | — | — | 1 | 5.76 |
| CHEMBL2408633 | — | — | 1 | 5.71 |
| CHEMBL4467163 | — | — | 1 | 5.71 |
| CHEMBL4447657 | — | — | 1 | 5.57 |
| CHEMBL4443018 | — | — | 1 | 5.42 |
| CHEMBL4453213 | — | — | 1 | - |
| CHEMBL4542552 | — | — | 1 | - |
| CHEMBL4572398 | — | — | 1 | - |
| CHEMBL4473500 | — | — | 1 | - |
| CHEMBL4530290 | — | — | 1 | - |
| CHEMBL4443023 | — | — | 1 | - |
| CHEMBL4592655 | — | — | 1 | - |
| CHEMBL4464262 | — | — | 1 | - |
| CHEMBL4527223 | — | — | 1 | - |
| CHEMBL4461166 | — | — | 1 | - |
| CHEMBL4469452 | — | — | 1 | - |
| CHEMBL4531344 | — | — | 1 | - |
| CHEMBL4452750 | — | — | 1 | - |
| CHEMBL4524803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4557603 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL4531443 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL4458847 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL4453443 | — | IC50 | = | 942.0 | nM | 6.03 |
| CHEMBL4585408 | — | IC50 | = | 971.0 | nM | 6.01 |
| CHEMBL4452940 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4574644 | — | IC50 | = | 1325.0 | nM | 5.88 |
| CHEMBL4453601 | — | IC50 | = | 1352.0 | nM | 5.87 |
| CHEMBL4472207 | — | IC50 | = | 1402.0 | nM | 5.85 |
| CHEMBL4592144 | — | IC50 | = | 1629.0 | nM | 5.79 |
| CHEMBL4461148 | — | IC50 | = | 1652.0 | nM | 5.78 |
| CHEMBL4460750 | — | IC50 | = | 1718.0 | nM | 5.76 |
| CHEMBL4467163 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL2408633 | — | IC50 | = | 1967.0 | nM | 5.71 |
| CHEMBL4447657 | — | IC50 | = | 2717.0 | nM | 5.57 |
| CHEMBL4443018 | — | IC50 | = | 3784.0 | nM | 5.42 |
| CHEMBL3342770 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4577468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4525823 | — | IC50 | - | — | - | |
| CHEMBL4456729 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4575608 | — | IC50 | - | — | - | |
| CHEMBL4476596 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4534257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4554202 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4562424 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4516271 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4461413 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4561313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4450287 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4453600 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2408632 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4467830 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4527253 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4527223 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4453213 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4542552 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4572398 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4473500 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4530290 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4443023 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4592655 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4464262 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4069786 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4461166 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4469452 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4531344 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4452750 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4524803 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4462458 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4565611 | — | IC50 | - | — | - |