Assay Detail
ADMET
CHEMBL4396023
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Antiproliferative activity against HEK293 cells incubated for 72 hrs by by CCK8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Dioxino[2,3-f]quinazoline derivative VEGFR-2 inhibitors exerting significant antipro-liferative activity in HUVECs and mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.69 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4516513 | — | — | 1 | 6.16 |
| CHEMBL4528373 | — | — | 1 | 6.05 |
| CHEMBL4449250 | — | — | 1 | 6.00 |
| CHEMBL4455006 | — | — | 1 | 5.93 |
| CHEMBL4466426 | — | — | 1 | 5.54 |
| CHEMBL4435366 | — | — | 1 | 5.45 |
| CHEMBL4581503 | — | — | 1 | 5.29 |
| CHEMBL4514617 | — | — | 1 | 5.12 |
| CHEMBL4531859 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4516513 | — | IC50 | = | 699.9 | nM | 6.16 |
| CHEMBL4528373 | — | IC50 | = | 894.1 | nM | 6.05 |
| CHEMBL4449250 | — | IC50 | = | 994.0 | nM | 6.00 |
| CHEMBL4455006 | — | IC50 | = | 1164.0 | nM | 5.93 |
| CHEMBL4466426 | — | IC50 | = | 2882.0 | nM | 5.54 |
| CHEMBL4435366 | — | IC50 | = | 3563.0 | nM | 5.45 |
| CHEMBL4581503 | — | IC50 | = | 5183.0 | nM | 5.29 |
| CHEMBL4514617 | — | IC50 | = | 7541.0 | nM | 5.12 |
| CHEMBL4531859 | — | IC50 | > | 25000.0 | nM | - |