Compound Detail
CHEMBL4455006
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
O=C(Nc1ccc(Oc2ncnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)cc1F)Nc1cc(C(F)(F)F)ccc1F
Basic Information
| ChEMBL ID | CHEMBL4455006 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IAINQPVVZAMDKF-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
661.6
MW (Da)
6.24
ALogP
9
HBA
2
HBD
116.3
PSA (Ų)
0.16
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| HUVEC CHEMBL613979 | IC50 | 8.33 | 8.33 | 4.7 | 1 |
| HEK293 CHEMBL614818 | IC50 | 5.93 | 5.93 | 1164.0 | 1 |
| L02 CHEMBL4296457 | IC50 | 5.82 | 5.82 | 1512.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356... | 31096155 |
| HUVEC | IC50 | = | 4.7 | nM | 8.33 | Inhibition of VEGF-induced cell proliferation of HUVEC incubated for 72 hrs by b... | 31096155 |
| HEK293 | IC50 | = | 1164.0 | nM | 5.93 | Antiproliferative activity against HEK293 cells incubated for 72 hrs by by CCK8 ... | 31096155 |
| L02 | IC50 | = | 1512.0 | nM | 5.82 | Antiproliferative activity against human LO2 cells incubated for 72 hrs by by CC... | 31096155 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31096155 | 10.1016/j.ejmech.2019.04.015 | Vascular endothelial growth factor receptor 2 | 1 |
| 31096155 | 10.1016/j.ejmech.2019.04.015 | HEK293 | 1 |
| 31096155 | 10.1016/j.ejmech.2019.04.015 | L02 | 1 |
| 31096155 | 10.1016/j.ejmech.2019.04.015 | HUVEC | 1 |
Data from ChEMBL 36 via Core Engine