Assay Detail
ADMET
CHEMBL4397221
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Inhibition of CYP3A4 (unknown origin) by fluorescence-based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.19 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4593524 | — | — | 1 | 5.51 |
| CHEMBL4573171 | — | — | 1 | 5.23 |
| CHEMBL4541964 | ZATOLMILAST | 3.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4593524 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4573171 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4541964 | ZATOLMILAST | IC50 | = | 15000.0 | nM | 4.82 |