Assay Detail
Binding
CHEMBL4399057
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Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cell membranes incubated for 2 hrs by liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Endomorphin-2 analogs containing modified tyrosines: Biological and theoretical investigation of the influence on conformation and pharmacological profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.60 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4514319 | — | — | 1 | 9.59 |
| CHEMBL331325 | — | — | 1 | 9.09 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.53 |
| CHEMBL4475274 | — | — | 1 | 8.36 |
| CHEMBL4466953 | — | — | 1 | 8.30 |
| CHEMBL4527584 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4514319 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL331325 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 2.95 | nM | 8.53 |
| CHEMBL4475274 | — | Ki | = | 4.38 | nM | 8.36 |
| CHEMBL4466953 | — | Ki | = | 4.98 | nM | 8.30 |
| CHEMBL4527584 | — | Ki | = | 18.91 | nM | 7.72 |