Assay Detail
Binding
CHEMBL4399071
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Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.10 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 7.38 |
| CHEMBL1201195 | CEFMETAZOLE | 4.0 | 1 | 5.16 |
| CHEMBL1219 | RABEPRAZOLE | 4.0 | 1 | 4.96 |
| CHEMBL1237046 | ROLITETRACYCLINE | 2.0 | 1 | 4.00 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1201195 | CEFMETAZOLE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1219 | RABEPRAZOLE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1237046 | ROLITETRACYCLINE | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL164 | MYRICETIN | IC50 | = | 100000.0 | nM | 4.00 |