Assay Detail
Binding
CHEMBL4400642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.49 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457145 | — | — | 1 | 10.00 |
| CHEMBL4529443 | — | — | 1 | 10.00 |
| CHEMBL4546082 | — | — | 1 | 9.15 |
| CHEMBL4464314 | — | — | 1 | 9.10 |
| CHEMBL4441152 | — | — | 1 | 8.92 |
| CHEMBL4582194 | — | — | 1 | 8.85 |
| CHEMBL4538007 | — | — | 1 | 8.77 |
| CHEMBL4450585 | — | — | 1 | 8.62 |
| CHEMBL4552641 | — | — | 1 | 8.32 |
| CHEMBL4285743 | — | — | 1 | 8.22 |
| CHEMBL4461477 | — | — | 1 | 8.14 |
| CHEMBL4519897 | — | — | 1 | 8.09 |
| CHEMBL4459887 | — | — | 1 | 7.81 |
| CHEMBL4574253 | — | — | 1 | 7.69 |
| CHEMBL3629438 | — | — | 1 | 7.68 |
| CHEMBL4459492 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457145 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4529443 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4546082 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4464314 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4441152 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4582194 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4538007 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4450585 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4552641 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4285743 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4461477 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4519897 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4459887 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL4574253 | — | IC50 | = | 20.3 | nM | 7.69 |
| CHEMBL3629438 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4459492 | — | IC50 | = | 306.0 | nM | 6.51 |